For the convenience of users, particularly for the vast majority of experimental scientists, a publicly accessible web-server for Enhancer-IF has been established. Moreover, to maximize users' convenience, given below a step-by-step guide on how to use it to get the desired results without the need to through the above mathematical details.

Step 1. Copy the following link thegleelab.org/Enhancer-IF to the web browser and you will see its top page of Enhancer-IF. Click on the ReadMe button to see a brief introduction about the server

Step 2. We developed Cell-Specific prediction model for eight different cell types. Therefore, it is essential to select an appropriate Cell type for the prediction. Once the user selected the Cell-Specific model , it will direct to Step 3.

Step 3. Enter the query DNA sequences into the input box at the center . You can also directly upload input file via the Browse button. The input sequences should be in the FASTA format .

Step 4. By clicking on the button submit, you will get the predicted results on the screen of your computer. The first, the second, the third and the fourth column respectively represent serial number, user FASTA ID, Enhancers or Non-enhancers and probability of Enhancers.

Step 5. Click on the Reset button to clear the query sequences you enter to the input box.

Step 6. Click on the Dataset button to download the datasets (training and independent) used in this paper.